We collect cookies to analyze our website traffic and performance; we never collect any personal data.Cookies Policy
Accept
Michigan Post
Search
  • Home
  • Trending
  • Michigan
  • World
  • Politics
  • Top Story
  • Business
    • Business
    • Economics
    • Real Estate
    • Startups
    • Autos
    • Crypto & Web 3
  • Tech
  • Lifestyle
    • Lifestyle
    • Food
    • Beauty
    • Art & Books
  • Health
  • Sports
  • Entertainment
  • Education
Reading: The Gene-Synthesis Revolution
Share
Font ResizerAa
Michigan PostMichigan Post
Search
  • Home
  • Trending
  • Michigan
  • World
  • Politics
  • Top Story
  • Business
    • Business
    • Economics
    • Real Estate
    • Startups
    • Autos
    • Crypto & Web 3
  • Tech
  • Lifestyle
    • Lifestyle
    • Food
    • Beauty
    • Art & Books
  • Health
  • Sports
  • Entertainment
  • Education
© 2024 | The Michigan Post | All Rights Reserved.
Michigan Post > Blog > Tech / Science > The Gene-Synthesis Revolution
Tech / Science

The Gene-Synthesis Revolution

By Editorial Board Published November 24, 2021 4 Min Read
Share
The Gene-Synthesis Revolution
28Mag Synthesis 1 facebookJumbo

At Ginkgo, the synthesized DNA is then inserted into a host cell, perhaps yeast, which starts producing enzymes and peptides. Trial and error follow. Maybe the outputs from the first gene sequence are too floral, not spicy enough; maybe the ones from the second gene sequence have the right scent, but the cells don’t produce enough of it. Once an effective prototype is found, Ginkgo increases its production by growing the yeast in large vats and streamlining a process for extracting the desired molecules from the soup. What Ginkgo delivers is a recipe and ingredients — the winning genetic code, the host cell and the conditions in which the cells have to be nurtured — which the client can then use on its own.

Ginkgo’s platform first attracted customers in the fragrance industry, but in the last two years it has been partnering with pharmaceutical companies to search for new therapeutics. One such project is seeking to discover the next generation of antibiotics, in order to counter antibiotic resistance. Lucy Foulston, whose background is in molecular microbiology, is leading the effort; Tom Keating, a chemist, is working with her. Together, they highlighted for me a beautiful, twisted paradox — most antibiotics, and most antibiotic resistance, come from bacteria themselves. Bacteria carry genetic snippets with instructions to produce antimicrobial molecules that kill other bacteria. Typically they also have a capacity for self-resistance, so that the bacteria making a particular antibiotic avoid killing themselves, but this resistance can be transferred among bacteria, so that it becomes widespread.

Historically, two paths have been taken to come up with new antibiotics. The first, celebrated in stories of Alexander Fleming and moldy bread, is to seek them in the natural world: Scientists go out, obtain a little bit of soil from a geyser or coral reef, put what they find in a petri dish and see whether it kills any interesting bacteria. The second approach is to comb through chemical libraries in search of molecules that show antibacterial activity. Together, these two approaches gave us a steady supply of new antibiotics up until the 1980s and ’90s, when discoveries began to dry up.

“There was a lot of speculation,” Keating says. “Did we find all the useful ones? Did we find everything that was easy to find? Did we run into bacteria that are now so difficult to kill that the new ones we find don’t really work on them?” Whatever the reason, the reality is that we’ve been running out of new antibiotics in the face of growing antibiotic resistance.

‘I think what we’re just scratching the surface of is, can we program biology to do what chemists have traditionally done.’

The antibiotics project at Ginkgo is looking through bacterial genomes for segments encoded to generate novel antimicrobials. The sequencing efforts of the ’90s and 2000s yielded large databases of bacterial genomes, both public and private, that have given scientists an increasingly sophisticated understanding of which genes produce which molecules. And scientists have also developed the necessary techniques to, as Foulston says, “take these genes out, put them in another bacterial strain” — one they know how to work with — “and then coax that particular strain to produce the molecule of interest.”

Keating continues: “We don’t need the organism anymore. We don’t need it to be growing on a plate. We don’t need it to be killing anything else. All we need is the code.”

TAGGED:2021 tech and designAntibioticsBacteriaBiology and BiochemistryBiotechnology and BioengineeringChemistryCrispr (DNA)DNA (Deoxyribonucleic Acid)Genetics and HeredityGinkgo Bioworks IncSynthetic BiologyThe Washington Mail
Share This Article
Facebook Twitter Email Copy Link Print

HOT NEWS

World champion sprinter Sha’Carri Richardson arrested for allegedly assaulting boyfriend at Washington airport

World champion sprinter Sha’Carri Richardson arrested for allegedly assaulting boyfriend at Washington airport

World
August 2, 2025
Hamas responds to disarmament experiences as well being officers say 18 killed in Israeli fireplace – together with folks making an attempt to entry meals

Hamas responds to disarmament experiences as well being officers say 18 killed in Israeli fireplace – together with folks making an attempt to entry meals

Hamas has stated it won't disarm until an impartial Palestinian state is established with Jerusalem…

August 2, 2025
Hamas responds to disarmament experiences as well being officers say 18 killed in Israeli fireplace – together with folks making an attempt to entry meals

Hamas says it won’t disarm until an unbiased Palestinian state is established as Israeli hearth kills 18 in Gaza

Hamas has stated it won't disarm until an unbiased Palestinian state is established with Jerusalem…

August 2, 2025
Letters to Sports activities: Why did the Dodgers preserve their arms in pockets at commerce deadline?

Letters to Sports activities: Why did the Dodgers preserve their arms in pockets at commerce deadline?

p]:text-cms-story-body-color-text clearfix"> The self-confident, stay-as-they-are Dodgers did proper by not panicking on the commerce deadline…

August 2, 2025
World champion sprinter Sha’Carri Richardson arrested for allegedly assaulting boyfriend at Washington airport

SpaceX brings new crew to Worldwide House Station in simply 15 hours – nevertheless it’s nonetheless wanting Russian document

SpaceX has efficiently delivered a brand new group of astronauts to the Worldwide House Station…

August 2, 2025

YOU MAY ALSO LIKE

Tech corporations are racing to make their merchandise smaller – and far, a lot thinner

A few of the world's main tech corporations are betting massive on very small improvements.Final week, Samsung launched its Galaxy…

Tech / Science
August 2, 2025

Tesla ordered to pay $243m to victims of deadly Autopilot crash

A jury has dominated that Tesla is partly responsible for the demise of a younger lady who was hit by…

Tech / Science
August 2, 2025

Trump ally calls for giant tech ‘united entrance’ to battle UK and EU on-line security legal guidelines

A "united front" of US social media giants may attempt to "fight off" regulation applied in Europe, an American politician…

Tech / Science
August 1, 2025

Report-breaking child born from oldest ever embryo

The world's "oldest baby" has been born in america.Getting into the world on 26 July, Thaddeus Daniel Pierce was born…

Tech / Science
July 31, 2025

Welcome to Michigan Post, an esteemed publication of the Enspirers News Group. As a beacon of excellence in journalism, Michigan Post is committed to delivering unfiltered and comprehensive news coverage on World News, Politics, Business, Tech, and beyond.

Company

  • About Us
  • Newsroom Policies & Standards
  • Diversity & Inclusion
  • Careers
  • Media & Community Relations
  • Accessibility Statement

Contact Us

  • Contact Us
  • Contact Customer Care
  • Advertise
  • Licensing & Syndication
  • Request a Correction
  • Contact the Newsroom
  • Send a News Tip
  • Report a Vulnerability

Term of Use

  • Digital Products Terms of Sale
  • Terms of Service
  • Privacy Policy
  • Cookie Settings
  • Submissions & Discussion Policy
  • RSS Terms of Service
  • Ad Choices

© 2024 | The Michigan Post | All Rights Reserved

Welcome Back!

Sign in to your account

Lost your password?